The objective of this study is to assess the efficacy of Adductor-Canal-Blockade on pain and morphine consumption after total knee arthroplasty. Our hypothesis is that the Adductor -Canal-Blockade is superior to placebo in reducing pain and morphine consumption after total knee arthroplasty.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
40
US-guided Adductor-Canal-Blockade with ropivacaine 7,5 mg/ml
US-guided Adductor-Canal-blockade with saline
Department of Anaesthesia-Surgery-Intensive Care, Gentofte Hospital
Gentofte Municipality, Hellerup, Denmark
Pain during 45 degrees active flexion of the knee
0-100 mm at a visual analogue scale (VAS), at 1 hour postoperative
Time frame: 1 hour postoperative
Pain during 45 degrees active flexion of the knee
0-100 mm at a visual analogue scale (VAS), registered at the intervals 1, 2, 3, 4, 5 and 6 hours postoperative, calculated as "the area under the curve" (AUC) for the interval 1-6 hours postoperative.
Time frame: 0-6 hours postoperative
Pain during rest
0-100 mm at a visual analogue scale (VAS), registered at the intervals 1, 2, 3, 4, 5 and 6 hours postoperative, calculated as "the area under the curve" (AUC) for the interval 1-6 hours postoperative.
Time frame: 1-6 hours postoperative
A change in pain score in the ropivacaine group, after activating the block
0-100 mm at a visual analogue scale (VAS), at 30 and 60 minutes postoperative. A change in pain score in the ropivacaine group compared to the placebo group, after activating the block.
Time frame: 30-60 minutes postoperative
Total morphine consumption
Total morphine consumption at the interval 30 minutes - 6 hours postoperative.
Time frame: 30 minutes - 6 hours postoperative
Postoperative nausea
Nausea scores(0-3)registered at 1, 2, 3, 4, 5 and 6 hours postoperative, calculated as mean value for the interval 1-6 hours postoperative.
Time frame: 1-6 hours postoperative
Postoperative vomiting
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Number of vomiting episodes at the interval 1-6 hours postoperative.
Time frame: 1-6 hours postoperative
Zofran consumption
Total zofran consumption at the intervals 1-6 hours postoperative.
Time frame: 1-6 hours postoperative
Sedation
Sedation score (0-3) registered at 1, 2, 3, 4, 5 and 6 hours postoperative, calculated as the mean value for the interval 1-6 hours postoperative.
Time frame: 1-6 hours postoperative