Microvesicle Production After Acute Trauma and Its Clinical Impact on Venothromboembolism

Mayo Clinic1,234 enrolled

Overview

The purpose of this research study is to look at how trauma affects the ability of blood to clot. The blood of people who suffer a traumatic injury can under-clot or over-clot, and this research study will look at blood drawn from people after they suffer a traumatic injury to see how well their blood clots.

Study Type

OBSERVATIONAL

Enrollment

1,234

Conditions

Venothromboembolism

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male and female patients 18 years of age or older * Blunt trauma patients including those with closed head injury * Penetrating trauma patients Exclusion Criteria: * Are on therapeutic anticoagulation * Have preexisting coagulopathy * Patients greater than 12 hours from time of injury * Have history of malignancy or preexisting diagnosis of sepsis or renal failure * Patients with burn injuries * Male and female patients younger than 18 years of age * Pregnant patients

Locations (1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Estimate the distribution over time of procoagulant Microvesicles (MVs) concentration by cell of origin and endogenous thrombin potential (ETP).

Time frame: 6 months

Determine the cumulative incidence of Venothromboembolism (VTE) within three months after major trauma and test the distribution of procoagulant MV concentration and endogenous thrombin generation potential over time as potential predictors of VTE.

Time frame: 4 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.