Anti-Platelet Drugs and Brain-derived Neurotrophic Factor (BDNF) in Human Serum and Plasma

University of Rostock25 enrolled

Overview

The impact of anti-platelet drugs on the concentrations of Brain-derived neurotrophic factor (BDNF) in human plasma and serum is unknown. It is the aim of this study to investigate the impact of a single dose of Aspirin (500 mg) or Clopdigrel (600 mg) on the concentrations of Brain-derived neurotrophic factor (BDNF) in plasma and serum of healthy volunteers.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy Volunteers

Interventions

Aspirin and ClopidogrelDRUG

Intake of 500 mg Aspirin on day 1. Intake of 600 mg Clopidogrel on day 28. Blood collection for the measurement of platelet inhibition, platelet counts and BDNF, TGF-beta, 5-HT concentrations in peripheral blood on day 1 (before intake of 500 mg Aspirin), day 2 (24 hours after intake of 500 mg Aspirin), day 28 (before intake of 600 mg Clopidogrel), day 29 (24 hours after intake of 600 mg Clopidogrel).

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-50 years * Gender: Male Exclusion Criteria: * Any acute disease * Any chronic disease * Any medication * Allergies / Intolerance in association with Aspirin or Clopidogrel

Locations (1)

Dep. of Pneumology, University of Rostock

Rostock, Mecklenburg-Vorpommern, Germany

Outcomes

Primary Outcomes

BDNF plasma and serum concentration 24 hours after Aspirin or Clopidgrel intake

Time frame: 24 hours

Secondary Outcomes

5-HT and TGF-beta concentrations 24 hours after Aspirin or Clopidgrel intake

Time frame: 24 hours

Data from ClinicalTrials.gov

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