Essential Hypertension

Inclusion Criteria: * Males and females aged 18 to 75 years (inclusive) at screening. * Body mass index (BMI) between 18 and 35 kg/m2 (inclusive) and body weight at least 50 kg at screening and prior to enrollment. * 12-lead ECG without clinically relevant abnormalities measured at screening. * Clinical chemistry, hematology, coagulation, virus serology, and urinalysis test results not deviating to a clinically relevant extent from the normal range at screening. * Signed informed consent in the local language prior to any study-mandated procedure Exclusion Criteria: * Mean SBP \> 180 mmHg. * Severe, malignant, or secondary hypertension. * Episodes of hypertensive crisis or hypertensive emergency within 6 months prior to enrollment. * Previous history of fainting, collapse, syncope, orthostatic hypotension, or vasovagal reactions considered to be of clinical significance. * E6 Severe coronary artery disease indicated by myocardial infarction, percutaneous coronary intervention, or coronary artery bypass graft within the last 12 months prior to enrollment. * Angina pectoris within 6 months prior to enrollment