The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids on p38 MAPK in Asthma

Inclusion Criteria: * mild-to-moderate persistent asthmatics * FEV1 = OR \> 50% of predicted Exclusion Criteria: * Previous history of renal disease or serum creatinine is more than 2 mg/dl. * Previous history of liver disease. * Pregnancy or lactation. * Are already receiving or are known to be allergic to statins or to have developed myositis. * Have an asthma exacerbation requiring treatment with oral corticosteroids during the 3 months prior to the commencement of study entry. * Being treated with immunosuppressive agents. * Unwilling to cooperate the study.