Macrophage Migration Inhibitory Factor (MIF)- Cardiac Surgery

RWTH Aachen University100 enrolled

Overview

It has been repeatedly demonstrated that cardiac surgery with the use of extracorporeal circulation elicits a systemic inflammatory response and provokes ischemia-reperfusion related oxidative stress which could further lead to the development of organ failure in critically ill patients. Perioperative levels of macrophage migration inhibitory factor (MIF) and other inflammatory mediators could be involved in adverse outcomes in cardiac surgery.

The trace element selenium (Se) serves as an essential co-factor for the antioxidant enzymes Thioredoxin - reductase (TRR) and many other antioxidant enzymes, which protect tissues from oxidative stress. In septic patients it has previously been shown that thioredoxin, a TRR regulated Redox Enzyme, has the ability to suppress the synthesis of MIF. Aim of the present study is therefore to investigate the relation between perioperative selenium decrease and the reduction of TRR activity with a possible release of MIF during the inflammatory response after cardiac surgery.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Heart Surgery

Interventions

Blood samplingPROCEDURE

Blood sampling at various time points. Additional 92 mL blood.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * more than 18 years of age * open heart surgery and use of heart-lung-device * informed consent has been obtained Exclusion Criteria: * under 18 years of age * emergency cases * informed consent cannot be obtained * pregnancy or patient is breast-feeding

Locations (1)

RWTH Aachen University Hospital

Aachen, North Rhine-Westphalia, Germany

Outcomes

Primary Outcomes

Pilot study: correlation between clinical and lab parameters

To assess the importance of the MIF ligand/receptor family in a large cohort of patients (n=100) undergoing cardiac surgery and to characterize the underlying molecular events. Possible correlation between several clinical and laboratory parameters will be analyzed. This is a pilot study to generate hints at future items to be studied in controlled trials.

Time frame: two months

Secondary Outcomes

Secondary Outcome

* Correlation between perioperative MIF and MIF-2 levels and postoperative outcome * Measurement of sCD74/MIF complex * Determination of MIF polymorphism and its significance on clinical outcome * perioperative inflammation * organ injury

Time frame: two months

Data from ClinicalTrials.gov

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