Clinical and Biochemical Effects of Multipass Hemodialysis

Herlev Hospital12 enrolled

Overview

The purpose of this study is to investigate whether recycled dialysis fluid can supply enough clearance for hemodiaysis patients.

Conventional hemodialysis uses large amounts of water, which hinders travel possibilies for home hemodialysis (HD) patients. We have developed a recycling system using 25-30 l dialysate per dialysis. In vitro investigations show that this results in adequate dialysis. 12 HD patients will be studied during two dialysis sessions. The first HD will be a conventional 4 hour dialysis, using single pass dialysate. The second will be an 8-hour HD using multipass (recycled) dialysate 25-30 l. Clearance of urea, creatinine, phosphate and cobalamin will be measured both in the patient and the dialysate. Patient symptoms will be recorded.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Uremia

Interventions

Multipass hemodialysisDEVICE

8-hour dialysis using a recycled dialysis bath of 25-30 l

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Stable chronic HD patients * Informed consent Exclusion Criteria: * Age \<18 years * Psychiatric disease

Locations (1)

Herlev Hospital

Herlev, Denmark, Denmark

Outcomes

Primary Outcomes

Urea Kt/V

Time frame: 9 hours

Secondary Outcomes

Creatinine clearance

Time frame: 9 hours

Patient symptoms

Time frame: 9 hours

Data from ClinicalTrials.gov

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