It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEP) is present in grossly obese subjects especially in the supine position. The investigators tried to investigate the effect of low respiratory rate and high tidal volume on the intrinsic PEEP and gas exchange for obese subjects undergoing general anesthesia.
Impaired gas exchange is a common anesthetic problem in obese subjects. It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEPi) is present in grossly obese subjects especially in the supine position. It is known that there is a significant negative correlation between PEEPi present and PaO2. Therefore, the investigators postulated that if the reduce the PEEPi by reducing the respiratory rate in obese subjects, the impaired gas exchange might improve. The investigators tried to research the effect of low respiratory rate and high tidal volume on the intrinsic PEEP and gas exchange for obese subjects undergoing general anesthesia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
SINGLE
Enrollment
20
Seoul Medical Center
Seoul, South Korea
Gas change parameters
PaO2 and PaCO2 the result of arterial blood gas analysis
Time frame: 15 minute interval
intrinsic positive end-expiratory pressure
PEEPi measured by expiratory port occlusion method
Time frame: every 15 minutes
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Respiratory rate 6 Tidal volume 16.7 ml/kg external PEEP = 5
Respiratory rate 10 Tidal volume 10 ml/kg external PEEP = 5
Respiratory rate 16 Tidal volume 6.25 ml/kg external PEEP = 5