CANARY: Coronary Assessment by Near-infrared of Atherosclerotic Rupture-prone Yellow

Inclusion Criteria * Subject is at least 18 years of age * Subject is scheduled for an elective coronary catheterization * Subject is willing and able to provide informed written consent prior to the index catheterization * LipiScan IVUS CIS use is not contra-indicated * At least one submitted Chemogram is obtained entirely within a native coronary artery * Patient has been diagnosed with: stable angina (CCS I or CCS II);a positive functional test for ischemia (within the preceding 30 days); OR Stabilized acute coronary syndrome (unstable angina (CCS III, or CCS IV), non STEMI, or STEMI with no chest pain or other cardiac symptoms for \>24 hours * Blood cardiac biomarker (i.e. troponin I, CK-MB) levels less than the local laboratory ULN within 12 hours of the time of PCI guidewire placement. * Subject is to undergo PCI of a single lesion in a single native coronary artery during the enrollment procedure. * There is prior intent to treat the target lesion as part of the patient's clinical care. * The target lesion angiographic stenosis visually estimated as \>=50% and \<100% * The target lesion reference vessel diameter must be \>=2.5mm (visually estimated) * Total target lesion length must be ≤60 mm (visually estimated) * The minimum landing zone requirements for the FilterWire device can be met. * There must be no major side branches (\>2.0 mm in diameter) within the target lesion. * There must be no major side branches (\>2.0mm in diameter) between the target lesion and the filter nitinol loop landing zone. Exclusion Criteria * Subject is currently, or within the preceding 30 days, participating in a device or pharmaceutical treatment protocol. * Subject life expectancy at time of enrollment is less than 2 years; * Subject is pregnant or suspected to be pregnant at time of enrollment * Prior coronary bypass graft surgery (CABG) * PCI performed within the 24hours prior to the start of the study procedure * A PCI is planned within the 30 days following the enrollment procedure. * Unable to take aspirin and a thienopyridine for at least 30 days * Patient experienced a STEMI or non STEMI within the past 24 hours * Documented LVEF \<25% * the patient has multi-lesion or multi-vessel disease requiring revascularization of multiple lesions during the enrollment catheterization * Any angiographic evidence of thrombus in any coronary artery * There is evidence of dissection or procedural complication prior to randomization * Patient has unprotected left main (≥50% stenosis) or left main equivalent disease * Target Lesion is located in the distal segment of the target native coronary artery * Proximal bound of the target lesion is located within 3mm of the ostium of the target vessel or major side branch (\>2mm diameter by visual estimate) * Target lesion is excessively calcified