Trenev Trio/Healthy Trinity for Symptoms of Diarrhea-predominant Irritable Bowel Syndrome (IBS) and Functional Dyspepsia

Inclusion Criteria: 1. Age 18 to 75 years 2. Diagnosed with IBS-D including: a) weekly average of worst abdominal pain in the last 24 hours of ≥3 on a 0-10 scale, and b) weekly average of Bristol Stool form of ≥6 on a 1-7 scale 3. Diagnosed with functional dyspepsia defined as presence of at least one of the following symptoms: bothersome postprandial fullness, early satiation, epigastric pain, or epigastric burning AND no evidence of structural disease that is likely to explain the symptoms 4. History of IBS-D and dyspepsia symptoms for at least 12 weeks 5. Agree to use contraception throughout study period, unless postmenopausal or surgically sterile (females only) 6. Able to understand the nature and purpose of the study including potential risks and side effects 7. Willing to consent to study participation and to comply with study requirements 8. Successful completion of 2-week placebo-only run-in period, defined as ≥90% product compliance and completion of required questionnaires Exclusion Criteria: 1. Major gastrointestinal complication, e.g. Crohn's disease or ulcer 2. Prior abdominal surgery with the exception of hernia repair and appendectomy 3. Subjects over 60 years who have not had a sigmoidoscopy or colonoscopy in the past 10 years 4. Clinically significant systemic disease 5. Life expectancy \< 6 months 6. Pregnant female or breastfeeding 7. Lactose intolerance 8. Immunodeficient subjects 9. Anti-psychotic medication within the prior 3 months or major psychiatric disorder within the past 2 years 10. Systemic steroids within the prior month 11. Current treatment with nasogastric tube, ostomy, or parenteral nutrition 12. Use of proton pump inhibitors 13. Eating disorder 14. Recent (\< 2 weeks) antibiotic administration 15. History of alcohol, drug, or medication abuse 16. Daily consumption of probiotics, fermented milk, and/or yogurt 17. Known allergies to any substance in the study product 18. Participation in another study with any investigational product within 3 months of screening