Hematologic Toxicity Observation of the Docetaxel+ Cisplatin+ Fluorouracil (TPF)Medical Protocol

Groupe Oncologie Radiotherapie Tete et Cou130 enrolled

Overview

The ending of this study is to describe the effect of febrile neutropenia on patients who receive a chemotherapy by docetaxel+cisplatin+fluorouracil(TPF).

In this study we will describe * habits of medical staff in prescription of growth factors or antibiotic prophylaxis * ratio of patients treated by growth factors in primary or secondary prophylaxis * ratio of patients treated in primary prophylaxis who present a febrile neutropenia * ratio of patients who need to be hospitalized and the duration of those hospitalizations. * causes of lateness, of decreasing, and of stop of chemotherapy * antibiotic and growth factors prophylaxis tolerance .

Study Type

OBSERVATIONAL

Enrollment

130

Conditions

Squamous Cell Head and Neck Carcinoma

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with histologically proved head and neck squamous cell carcinoma * age: more than 18 * patients who are beginning a chemotherapy (docetaxel+cisplatin+ 5FU) * patients must have been informed of automatic data processing concerning them. Exclusion Criteria: * previous chemotherapy for the head and neck squamous cell carcinoma * previous chemotherapy for an other cancer in the two years before * intercurrent illness that could significantly interfere with chemotherapy such as HIV infection, infection or active febrile illness, a chronic intestinal disease

Locations (18)

Institut Sainte Catherine

Avignon, France

Centre Hospitalier Universitaire

Besançon, France

Polyclinique de Bordeaux Nord

Outcomes

Primary Outcomes

biologic blood counts

evaluation of medical status evaluation of hematologic toxicity description of clinic toxicity: fever, sepsis..

Time frame: blood test before every chemotherapy up to 4 months

Data from ClinicalTrials.gov

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