The Effects of Preoperative Aspirin on Graft Patency and Cardiac Events in Off-pump Coronary Artery Bypass

Chinese Academy of Medical Sciences, Fuwai Hospital200 enrolled

Overview

Antiplatelet therapy is critical in the management of coronary artery disease.For patients undergoing off-pump coronary artery bypass graft,controversy remains regarding the safety of preoperative antiplatelet therapy.And there is little study about the effect of continuing aspirin until the surgery day on graft patency.So we would like to perform this study to evaluate the effects of preoperative aspirin on graft patency and cardiac events in off-pump coronary bypass.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

200

Conditions

Coronary Artery Disease Off-pump Coronary Artery Bypass Aspirin

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing elective, off-pump coronary artery bypass with at least two grafts * patient able to give informed consent Exclusion Criteria: * on-pump CABG * combined with the valve surgery * Preoperative use of clopidogrel and warfarin * allergy to aspirin * History of severe liver disease * History of bleeding diathesis,significant GI bleed * Patient has known renal failure or contraindication for Cardiac CT Angio * Redo CABG

Outcomes

Primary Outcomes

graft patency examined by CT scan

we would like to compare the graft patency within the one week after the surgery between the preoperative aspirin use and preoperative nonuse.We just want to know wether preoperative aspirin use could improve the graft patency in off-pump coronary artery bypass.

Time frame: one week after surgery

Secondary Outcomes

Bleeding, transfusion, re-exploration

Time frame: perioperative