Protective Effect of N-acetylcysteine Against From Ototoxicity

TC Erciyes University60 enrolled

Overview

Peritonitis is currently one of the leading complications of continuous ambulatory peritoneal dialysis (CAPD). Aminoglycosides and vancomycin are used in the treatment of CAPD peritonitis despite their potential risk for ototoxicity. NAC is a molecule used in the treatment and prophylaxis of many diseases related to oxidative stress. The aim of this study was to examine whether ototoxicity due to antibiotics used in the treatment of CAPD peritonitis can be prevented by N-acetylcysteine

NAC, a thiol-containing antioxidant because of this,we want to investigate antioxidant status.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Hearing Loss, Extreme

Interventions

N-acetylcysteineDRUG

N-acetylcysteine 600 mg twice a day,one week after administration of antibiotics

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * End-stage renal disease * Undergoing continuous ambulatory peritoneal dialysis as a renal replacement therapy * Developing the first continuous ambulatory peritoneal dialysis related peritonitis episode Exclusion Criteria: * Being treated with aminoglycoside antibiotics and vancomycine within the previous 3 months * Detection of mechanical occlusion of external ear * Having signs of disturbed integrity of tympanic membrane on otoscopy or tympanometry * History of a continuous ambulatory peritoneal dialysis related peritonitis

Locations (1)

Erciyes University

Kayseri, Turkey (Türkiye)

Outcomes

Primary Outcomes

Threshold hearing levels

Ototoxicity was defined as an increase in the auditory threshold by at least 20 dB at any one test frequency, or at least 10 dB at any two adjacent frequencies, or loss of response at three consecutive frequencies between the baseline and follow-up studies in the worse ear.

Time frame: 4 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.