Incorporating Avocados in Meals

Loma Linda University30 enrolled

Overview

The purpose of this study is to examine the effect of incorporating avocados in meals on post-ingestion glycemic index, insulin response, sensations of satiety and on appetite-related gastrointestinal peptide and hormone release. Also the effect of consuming avocado containing meals on the caloric intake of participants in subsequent eating episodes will be explored. Each subject will participate in one intervention for one day, wait one or two weeks, come for another intervention, wait one or two weeks and come for a final intervention- three in total. Participants will be randomly assigned to one of six treatment sequences. Postprandial response to the control and two avocado-containing test meals will be assessed and compared using a 3 x 3 single blind cross-over design. The Subjects will be between 25 and 60 years old, female or male, with a BMI of 23 to 32, stable weight, no sports involvement, non-smoking and not dependent on caffeine. Thirty subjects will be recruited.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

SINGLE

Enrollment

Conditions

Satiety Glycemic Index Insulin Gastrointestinal Peptides and Hormones

Interventions

Avocado supplementDIETARY_SUPPLEMENT

Calories from avocados replace calories of the control lunch

Avocado includedDIETARY_SUPPLEMENT

Calories from avocados will be added to calories from the control lunch

Eligibility

Sex: ALLMin age: 23 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 23-60 years old * BMI 23-32 * Stable weight for 6 months * Live or work near Loma Linda University Exclusion Criteria: * Smoker * Heavy involvement in sports * Dependent on caffeine

Locations (1)

Loma Linda University, Department of Nutrition

Loma Linda, California, United States

Outcomes

Primary Outcomes

Satiety

The effect that consumption of avocados has on feelings of fullness and the quantity of food consumed in a subsequent eating episode

Time frame: 12 hours

Secondary Outcomes

post-ingestion glycemic index

Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. The glycemic index will be analyzed.

Time frame: 3 hours

insulin response

Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. Insulin response will be analyzed.

Time frame: 3 hours

appetite-related gastrointestinal peptide and hormone release

Blood will be drawn at 30 minutes, 60 minutes, 120 minutes and 180 minutes after consumption of a meal with or without avocados. Gastrointestinal peptide and hormones will be analyzed.

Time frame: 3 hours

Data from ClinicalTrials.gov

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