Adiponectin and Circulating Progenitor Cells (CPC) Function

University of Leipzig20 enrolled

Overview

Adiponectin and exercise training contribute to the maintenance of a normal vascular tone by influencing vascular NO bioavailability and concentration and function of endothelial progenitor cells. The molecular mechanisms are only partially understood. Therefore, aim of the present study is to elucidate the effects of Adiponectin on endothelial progenitor cell migration and the underlying signaling pathways. Furthermore, the impact of exercise training on adiponectin-mediated endothelial progenitor cell migration will be investigated.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Coronary Artery Disease

Interventions

exercise trainingOTHER

4 weeks supervised physical exercise training

Eligibility

Sex: MALEMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ≤ 75 years of age * stable coronary artery disease * preserved left ventricular function * physical work capacity of ≥ 50 * successful elective percutaneous coronary intervention at study begin Exclusion Criteria: * diabetes mellitus * hypercholesterolemia * untreated hypertension * smoking * myocardial infarction within the last 4 weeks * significant stenosis of the left main coronary artery

Locations (1)

University of Leipzig, Heart Center

Leipzig, Germany

Outcomes

Primary Outcomes

migratory capacity of endothelial progenitor cells towards an SDF-1 gradient

Time frame: 4 weeks

Data from ClinicalTrials.gov

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