Study of Dehydroepiandrosterone (DHEA) in Respiratory Pulmonary Hypertension in Adults (DHEA-HTAP)

Inclusion Criteria: * Age ≥ 18 years old and ≤ 75 years old * Chronic Obstructive Pulmonary Disease with FEVs/VC \< 70% (\*) * Respiratory pulmonary hypertension with mean pulmonary arterial pressure ≥ 20 mmHg (\*) related to normal pulmonary capillar pressure assessed by catheterization of the right side of the heart (pulmonary capillary wedge pressure ≤12mmHg) * PO2 ≤ 70 mmHg assessed by arterial gasometry at ease * If oxygenotherapy then oxygenotherapy more than 6 months before pre-screening * Written informed consent (\*) Criteria assessed from last health check or the last exams for COPD diagnosis Exclusion Criteria: * clinical instability and/or respiratory exacerbation dangerous for catheterization * Pregnancy (ßHCG \> 20 UI /l) or breastfeeding on going * General corticotherapy \> 0,5 mg/kg/day prednisolon equivalent * Hepatic insufficiency (TP \< 50%) or renal insufficiency (creatininemia \> 130 µmol/l) or diabetes mellitus type I or II (treated by oral antidiabetic or insulin) * Left-heart failure (coronary heart disease and/or left valvulopathy) * High level of prostatic specific antigen (PSA) (\> 7ng/ml) * Cancer antecedent or treatment on going