Effect of Cisatracurium Versus Atracurium on Intraocular Pressure in Patients Underwent General Anesthesia

Isfahan University of Medical Sciences90 enrolled

Overview

The purpose of this study is to determine which drug makes lower intraocular pressure

Increase in intraocular pressure (IOP) following tracheal intubation during general anesthesia can be troublesome. The investigators compared the influence of cisatracurium and atracurium on IOP in patients undergoing general anesthesia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

SINGLE

Enrollment

Conditions

Intraocular Pressure

Interventions

atracuriumDRUG

atracurium, Drop,0.5 mg/kg, one time, one day

cisatracuriumDRUG

cisatracurium, drop,0.15mg/kg,one time, one day

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: ASA class of I or II baseline IOP of lower than 20 mmHg stable hemodynamics no history of ophthalmic diseases not using drugs affecting IOP (e.g. anticholinergics, sympathomimetics) no contraindication for atracurium or cisatracurium administration. Exclusion Criteria: difficulty in mask ventilation or in tracheal intubation end expiratory CO2 of below 35 mmHg or over 45 mmHg O2 saturation of below 90%

Locations (1)

Al-zahra university hospital

Isfahan, Isfahan, Iran

Outcomes

Primary Outcomes

intraocular pressure

determining intraocular pressure in atracurium and cisatracurium groups

Time frame: at 2 minutes after intubation

Secondary Outcomes

systolic blood pressure

identification of systolic blood pressure in atracurium and cisatracurium groups

Time frame: at 2 minutes after intubation

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.