Nucleus accumbens plays important roles in the process of opiate addiction and initial of relapse after detoxification, deep brain stimulation of nucleus accumbens will inhibit its activity and thus to effectively prevent the relapse of the opiate dependence.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
20
Deep brain stimulation of bilateral nucleus accumbens
methadone maintenance treatment
Department of neurosurgery, Tangdu Hospital
Xi'an, Shaanxi, China
RECRUITINGTreatment retention
Opiate abstinent time by self-reports and monthly urinalysis for the patients undergo the deep brain stimulation of nucleus accumbens,treatment retention time for the methadone maintenance treatment patients
Time frame: 12 months
Change of participants' craving for opioid drugs
The 10-point visual analog scale (VAS),will be utilized at each time point. A participants' diary will be utilized at each time point.
Time frame: Baseline, 3 month, 6 month and 12month follow-up assessments
Change in Addiction Severity Index (ASI lite) composite scores
Time frame: Baseline, 3 month, 6 month and 12month follow-up assessments
Psychological evaluation
The Symptom Checklist - 90 (SCL-90) for evaluating general status, Self-Rating Depression Scale (SDS)for evaluating depression symptom,and Yale-Brown Obsessive Compulsive Scale (Y-BOCS) for evaluating obsessive compulsive symptom, will be utilized at each time point.
Time frame: Baseline, 3 month, 6 month and 12month follow-up assessments
Personality evaluation
The Eysenck Personality Questionnaire (EPQ)will be utilized at each time point.
Time frame: Baseline, 3 month, 6 month and 12month follow-up assessments
Cognitive evaluation
The Wechsler Memory Scale(WMS) for evaluating the memory will be utilized at each time point.
Time frame: Baseline, 3 month, 6 month and 12month follow-up assessments
Evaluation of quality of life
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The MOS item short from health survey(SF-36) be utilized at each time point.
Time frame: Baseline, 3 month, 6 month and 12 month follow-up assessments
Change in two static positron emission tomography(PET) images study
\[18F\]fluoro-D-glucose (FDG) for evaluating cerebral metabolism will be utilized at each time point.
Time frame: Baseline and 6month follow-up