Does the Negativation of the Glucose Hydrogen Breath Test Come Along With a Reduction of the Symptoms of Gaz Incontinence ?

University Hospital, Rouen16 enrolled

Overview

The objectives of this work are: 1/to estimate the frequency of a positive glucose breath test in favour of a small intestinal bacterial overgrowth in a population of patients consulting for gaz incontinence by comparison to a population of control subjects; 2/to estimate versus a conventional treatment the efficiency of an antibiotic treatment; in case of small intestinal bacterial overgrowth diagnosed by the glucose breath test, to improve gaz incontinence

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Anal Incontinence

Interventions

MetronidazoleDRUG

Metronidazole,per os,500mg, 3 per day during 10 days

CArbosylaneDRUG

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Gaz incontinence for more than 3 months * Afflilied to national health security * Having read and sign the information letter and consent form Exclusion Criteria: * Pregnancy * use of antibiotics, probiotics, IPP for less tha n 3 months * past of small intestinal bacterial overgrowth * ischemic, inflammatory colitis,colo-rectal cancer * diabetes * allergy to metronidazole * psychiatric disease * patients who do not speak or read french

Locations (1)

Physiology Unit, Hopital Charles Nicolle, 1 rue de Germont

Rouen, France

Outcomes

Primary Outcomes

number of gaz incontinence episodes

Time frame: 3 days before randomization and treatement and 3 days after 10 days of treatment (antibiotic or conventionnal treatment

Data from ClinicalTrials.gov

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