The purpose of this study is to determine whether probiotic bacterium Bifidobacterium longum (B. longum) can improve mood and bowel symptoms in patients with Irritable bowel syndrome (IBS). The patients will be treated with probiotic or placebo for 6 weeks. Their mood, memory, general well-being and bowel symptoms will be assessed before, at the end of the treatment and 4 weeks later. Brain activation pattern, changes in gut bacteria, metabolic profile and inflammatory markers will be also measured.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
40
Powder containing Bifidobacterium longum in maltodextrin.
Powder containing only maltodextrin
McMaster University Medical Center
Hamilton, Ontario, Canada
Hospital Anxiety and Depression (HAD) scale.
Change in anxiety and depression, assessed using Hospital Anxiety and Depression (HAD) scale, after six weeks of treatment.
Time frame: 6 weeks post-treatment initiation
Improvement in IBS symptoms.
Time frame: 6 and 10 weeks post-treatment
Improvement in objective biomarkers.
Time frame: 6 weeks post-treatment
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