Exclusive Intraoperative Radiation Therapy for Breast Cancer

Inclusion Criteria: * Non lobular epithelial breast carcinoma, excised with standard quadrantectomy * Age ≥ 45 and \< 85 * Tumor major diameter ≤ 2.5 cm * Negative surgical margins (≥ 5 mm) * Willingness to undergo follow up examinations * Willingness to undergo imaging examinations (MRI, mammograms, ultrasonography) * Signed informed consent Exclusion Criteria: * Ductal carcinoma in situ or lobular carcinoma * Extensive intraductal component (greater than 25%) or intraductal carcinoma with microinvasion * Serious concomitant disease or any disorder or condition (such as psychiatric or addictive disorders) that, in the opinion of the investigator, would preclude the patient from meeting the study requirements * Pregnancy or lactation at the time of enrolment proposal (if necessary, during the trial patients must use effective contraceptive device) * Collagen vascular disorders