A Study to Evaluate the Effect of a Proton-Pump Inhibitor (Rabeprazole) on the Relative Bioavailability of Cobimetinib in Healthy Participants

Inclusion Criteria * With a body mass index range of 18.5 to 29.9 kilograms per meter square (kg/m\^2) * In good health, determined by no clinically significant findings from medical history, 12-lead electrocardiogram (ECG), and vital signs * Clinical laboratory evaluations within the reference range for the test laboratory * Negative test for selected drugs of abuse at Screening (does not include alcohol) and at each Check-in * Negative hepatitis panel (including hepatitis B virus surface antigen \[HBsAg\] and hepatitis C virus antibody \[anti-HCV\]) and negative human immunodeficiency virus (HIV) antibody screens * Healthy males and females of nonchildbearing potential who agree to use effective contraception Exclusion Criteria * Significant history or clinical manifestation of any significant metabolic, allergic, dermatological, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal, neurological, or psychiatric disorder * History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, or other substance * History of stomach or intestinal surgery or resection that would potentially alter absorption and/or excretion of orally administered drugs, except that appendectomy, hernia repair, and/or cholecystectomy will be allowed * History or presence of an abnormal ECG * History of alcoholism or drug addiction within 1 year prior to Period 1 Check-in * Use of any tobacco- or nicotine-containing products within 6 months prior to Period 1 Check-in * Participation in any other investigational study drug trial in which receipt of an investigational study drug occurred within 30 days or 5 half-lives, whichever is longer, prior to Period 1 Check-in * Use of any prescription medications/products within 14 days prior to Period 1 Check-in * Use of any over-the-counter, non-prescription preparations within 7 days prior to Period 1 Check-in * Use of alcohol-, grapefruit-, or caffeine-containing foods or beverages within 72 hours prior to Period 1 Check-in * Poor peripheral venous access * Any acute or chronic condition that would limit the participant's ability to complete and/or participate in this clinical study * Female participant is pregnant, lactating, or breastfeeding * Use of PPIs or histamine H2 receptor antagonists within 1 month prior to Period 1 Check-in * Known hypersensitivity to rabeprazole or any of its components or to derived products of benzimidazoles * Predisposing factors to retinal vein occlusion (RVO)