The Impact of Deferasirox on Non-Alcoholic-Steatohepatitis

Inclusion Criteria (shortened): * Patients with elevated liver enzymes * Elevated serum ferritin (females \> 300 ng/ml, males \> 450 ng/ml) * Liver Histology consistent with a diagnosis of NASH Exclusion Criteria (shortened): * Alcohol intake \> 140 g/week * Established liver cirrhosis Child Pugh B or C * Copresence of other causes of chronic liver disease * Anemia \< 10 g/dl * Any elevation of liver enzymes \> 5 ULN (ALAT, ASAT, g-GT), \> 2.5 ULN (other), \> 1.5 (Bilirubin) * Serum creatinine \> 1.4 mg/dl or Ccr \< 60 ml/min * Hemochromatosis * Known allergy or contraindication to the administration of Deferasirox * Sexually active pre-menopausal female patients who are unable to use a highly effective method of birth control. An exception is made for those who have undergone clinically documented total hysterectomy and/or oophorectomy, tubal ligation. * Patients with impaired coagulation * History of blood transfusion during the 6 months prior to study entry * Oral iron supplementation within the last 4 weeks of study entry * Treatment with phlebotomy within 2 weeks of screening visit * Desferal treatment within 1 month of the screening visit * Patients currently or previously treated with deferiprone or Deferasirox * Presence of a surgical or medical condition that might significantly alter the absorption, distribution, metabolism or excretion of any study drug * Positive HIV serology * Patients with active inflammatory diseases that may interfere with the accurate measurement of serum ferritin * Patients with a diagnosis of a clinically relevant cataract or a previous history of clinically relevant ocular toxicity related to iron chelation * Pregnant or breast feeding patients * Patients treated with systemic investigational drug within 4 weeks prior or with topical investigational drug within 7 days prior to the screening visit * Medications with proven or suspected influence on NASH such as glitazones, statins, or metformin are no exclusion criteria for study entry (insulin is not regarded to interfere with NASH).