No comparative trial investigating the effect of preoperative chemotherapy for locally advanced pancreatic cancer on short-term postoperative outcome has been published so far. The aim of the present study is to assess the potential impact of preoperative chemotherapy on short-term postoperative outcome after pancreatic resection in a case-matched series of cancer patients.
Between 2003 and 2011, patients with locally advanced (stage III) pancreatic cancer who were treated with preoperative chemotherapy (PCHT) underwent surgical resection. Each patient was matched with the closest two patients with pancreatic cancer ( control group ) selected from our prospective electronic database who met the following match criteria: age (+/- 3 years), gender, ASA score, type of resection, pancreatic duct diameter (+/- 1 mm), and tumour size (+/- 5 mm).
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
150
Pancreatic resection after preoperative chemotherapy
Pancreatic resection
San Raffaele Hospital
Milan, Milan, Italy
Postoperative morbidity rate
Time frame: Postoperative. From 0 to 30 days after discharge
Postoperative mortality
Time frame: Postoperative. From 0 to 30 days after discharge
Length of hospital stay (LOS)
Time frame: Postoperative. From 0 to 30 days after discharge
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