The purpose of this study is to evaluate the antioxidant effect of Plantago asiatica L. extract in subjects with mild hyperlipidemia.
The purpose of this study is to evaluate an acute effect of Plantago asiatica L. extract consumption on antioxidative biomarkers in subjects with mild hyperlipidemia. Subjects will intake Plantago asiatica L. extract with a high fat meal for oxidative stress loading. Antioxidative biomarkers will be measured after single-dose administration of Plantago asiatica L. extract.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
40
Liquid (80g) containing Plantago asiatica L. extract 5g
Liquid (80g) containing Plantago asiatica L. extract 10g
Liquid (80g) containing Plantago asiatica L. extract 20g
Ewha Womans University / Hanaro Medical Foundation
Seoul, South Korea
Comet assay after single-dose consumption of Plantago asiatica L. extract
Time frame: measured 5 times over 6 hours(0, 60, 120, 240, 360 minutes)
Plasma FRAP
Time frame: measured 5 times over 6 hours(0, 60, 120, 240, 360 minutes)
Plasma MDA
Time frame: measured 5 times over 6 hours(0, 60, 120, 240, 360 minutes)
Plasma FFA
Time frame: measured 5 times over 6 hours(0, 60, 120, 240, 360 minutes)
Plasma ox-LDL
Time frame: measured 5 times over 6 hours(0, 60, 120, 240, 360 minutes)
Plasma erythrocyte SOD
Time frame: measured 5 times over 6 hours(0, 60, 120, 240, 360 minutes)
Plasma triglyceride
Time frame: measured 5 times over 6 hours(0, 60, 120, 240, 360 minutes)
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Liquid (80g) without Plantago asiatica L. extract