R-ESHAP Followed by Autologous Transplantation for Refractory or Relapsed Diffused Large B-cell Lymphoma

Inclusion Criteria: * Age range: 18-65 years old * Histological confirmed diffuse large B-cell lymphoma * Refractory or first relapsed disease * Prior anthracycline exposure * Measurable disease * ECOG performance status 0-1 * Life expectancy of more than 3 months * Bone marrow function: ANC≧1.5×109/L, PLT≧100×109/L, Hb≧90g/L * Liver function: total bilirubin, ALT and AST \<1.5×UNL * Renal function: Cr\<1.5×UNL, CCR≧50ml/min * No contraindication for transplantation Exclusion Criteria: * Evidence of CNS and bone marrow involvement * More than 1 type of chemotherapy regimens exposure * High level of HBV DNA * Contraindication of high-dose methylprednisolone * Pregnant or lactating women * History of other malignancies except cured basal cell carcinoma of skin and carcinoma in-situ of uterine cervix * History of allergic reaction/hypersensitivity to rituximab * Significant active infection