Endometrial Biopsy Protocol for In Vitro Fertilization (IVF)

Kaplan Medical Center200 enrolled

Overview

Endometrial biopsy has been shown to improve IVF pregnancy and live birth rates. The optimal time of performing the biopsy is yet to be established. In this study, the investigators will compare different temporal timing of the biopsies with regards to the menstrual cycle and their affect on the success rates of the treatment.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

200

Conditions

Infertility Recurrent Implantation Failure

Interventions

endometrial biopsy/iesPROCEDURE

performing office endometrial biopsy with a disposable sterile catheter

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 38 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * normal menstrual cycle * between 1-6 previous failed IVF cycles * normal hormonal profile Exclusion Criteria: * intrauterine procedure in last 3 months * hydrosalpinx * intrauterine lesion /malformation

Locations (2)

Kaplan Medical Center, IVF Unit

Rehovot, Israel

Weizmann Institute of Science

Rehovot, Israel

Outcomes

Primary Outcomes

pregnancy rates

Time frame: 2 years

Secondary Outcomes

live birth rates

Time frame: 3 years

Central Contacts

Dan Levin, M.D.

CONTACT

+972-89441623 dan_l@clalit.org.il

Irit Granot, Ph.D.

CONTACT

+972-8-9441623 irit_g@clalit.org.il

Data from ClinicalTrials.gov

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