CLL Empirical Antibiotic Regimen

Inclusion Criteria: * Age \> 18 * ECOG performance status of 2 or less. * CLL with a diagnostic score of 4 or 5. * Clinical stage A disease. * No disease progression over a minimum of 1 month prior to commencement of therapy. * Less than 2 adverse prognostic factors. * Absence of adverse cytogenetics. * Expected survival \> 6 months. * Able to give informed consent. * No clinical evidence of active infection at the time of study entry. * No known allergy to any of the study medications. * Renal and liver function tests within normal limits. Exclusion Criteria: * Disease progression during screening period. * Known positivity for HIV types 1 or 2. * Active infection at the time of screening. * Pregnancy or lactation. * Females of childbearing potential† and males not willing to practice an effective method of contraception whilst receiving the antibiotic regimen and for 4 weeks after the last dose. * Concomitant medication likely to produce serious interaction with study drugs including warfarin type oral anticoagulants and anti-epileptics.