Study of Anti-HB-EGF Antibody KHK2866 in Subjects With Advanced Solid Tumors and Ovarian Cancer

Inclusion Criteria: * Histologically or cytologically documented, measurable or non-measurable, advanced primary or recurrent solid tumor (Phase 1a only) which is unresponsive to standard therapy or for which there is no standard therapy available. * Histologically or cytologically documented ovarian, primary peritoneal, or fallopian tube cancer. * The subject has objective radiographic disease progression and either unmeasurable or measurable disease during or following the last treatment regimen, or serum cancer antigen-125 (CA-125) greater than 2X the upper limit of normal (\[ULN\] \>70 U/mL * Life expectancy \>3 months. * Performance status \< 3 at study entry. * Age \> 18 years. * Normal left ventricular ejection fraction. * Recovered from the effects of recent surgery, radiotherapy, chemotherapy, hormonal therapy, or other therapies for cancer * Preserved hepatic, renal, and hematopoetic organ function. * Male and female subjects must use medically accepted contraception. Exclusion Criteria: * Ovarian malignancy of low malignant potential. * Received anti-cancer chemotherapy, hormonal therapy, radiotherapy, immunotherapy, or investigational agents within 4 weeks prior to the first dose of KHK2866 (6 weeks for nitrosourea or mitomycin chemotherapy). * received Mabs or had major surgery within 4 weeks of the first dose of KHK2866. * Requires administration of a prohibited medication or treatment including: prophylactic use of erythroid and/or granulocyte colony stimulating factors; concurrent anti-cancer treatment; biologic response modifiers for any condition * Brain metastases, leptomeningeal or primary brain neoplasm, even if treated. * Previously untreated or uncontrolled epidural metastasis * Cerebrovascular accident, Transient ischemic attack; symptomatic head trauma, or seizures or any kind within 6 months * Dementia, or other disorders of mentation or difficulty speaking or difficulty with comprehension. * Suspected impending bowel obstruction * The subject is pregnant,or is lactating. * Significant uncontrolled intercurrent illness * Known HIV infection or AIDS-related illness. * Known active hepatitis B or C or other active liver disease. * Psychiatric illness, disability or social situation that would compromise the subject's safety, ability to provide consent, or limit his/her compliance with study requirements. * Experienced a unmanageable hypersensitivity reactions to Mabs or other therapeutic proteins. * History of second primary cancer, with the exception of: a) curatively resected non-melanomatous skin cancer; b) curatively treated cervical carcinoma in-situ; or c) other primary solid tumor treated with curative intent and no known active disease present and no treatment administered during the last 2 years. * Additional exclusion criteria for subjects proposed for enrollment into the Phase 1b portion: * History of hypersensitivity or infusion reaction to any of the proposed chemotherapy arm's agents that could not be controlled with pre-medication and/or infusion rate adjustment; * Prior treatment with KHK2866; * History of Grade ≥ 3 non-hematologic or Grade 4 hematologic toxicity attributable to any of the proposed chemotherapy arm's agents * For subjects proposed to receive treatment with KHK2866 plus PLD: prior total cumulative exposure to doxorubicin must be ≤ 240 mg/m2. * Subjects with a known history of interstitial lung disease or pulmonary fibrosis. Subjects must have pulse oximetry \>88% on room air at rest, and a DLco of \>49% if there is no evidence of lung metastasis.