In the current study the researchers will firstly investigate whether a bimanual coordination training protocol (20 min/day, for 8 consecutive weeks) correlates with changes in white matter architecture and improved upper-limb functionality in patients with multiple sclerosis. Secondly, the researchers predict that motor learning is more efficient when it is combined with anodal transcranial direct current (tDCS) stimulation on the left primary motor cortex.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
60
20 min, 1mA, 8 weeks (5 days a week, 20 min a day)
The training program consisted of a bimanual etch-a-sketch task. By rotating two wheels subjects have to match a line presented on the screen with the cursor. 8 weeks (5 days a week, 20 min a day)
Hasselt University (BIOMED)
Diepenbeek, Limburg, Belgium
Change in White Matter
Diffusion Tensor Imaging (DTI) T1 structural scan Fluid-attenuated inversion recovery Scan (FLAIR) Magnetization Transfer Imaging (MTI)
Time frame: Baseline, immediately after and 3 weeks after the intervention
Change in Quality of Life
Questionnaire
Time frame: Baseline, immediately after and 3 weeks after the intervention
Blood sample
BDNF Genotyping
Time frame: After the end of the study
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