A Pilot Study of 123I-MIP-1072 SPECT/CT Imaging With Optional Compact Gamma Camera Probe Imaging in Men With Prostate Cancer Undergoing Prostatectomy

Inclusion Criteria: * Participant must be scheduled to undergo standard of care prostatectomy for presumed localized prostate cancer at the NIH Clinical Center. * Have had or will undergo multiparametric endorectal coil 3T MR at the NIH clinical center * Recent (within 12 months of study entry) trans-rectal biopsy indicating the presence of adenocarcinoma of the prostate gland * Participant must be 18 years or older. * ECOG Performance grade of 0 to 2. (see Appendix 1) * Ability to understand and provide informed consent. All subjects must sign a document of informed consent indicating their understanding of the investigational nature and risks of the study before any protocol related studies are performed. * Participants of childbearing potential must agree to use an acceptable form of birth control, defined as abstinence, barrier or other acceptable, effective contraceptive method until 7 days after the infusion of study drug. Exclusion Criteria: * Participants for whom participating would significantly delay the scheduled standard of care therapy. * Subjects must not have prostate biopsies performed within 12 weeks before imaging; or within 8 weeks before imaging providing that the absence of hemorrhage is confirmed by MR imaging. * SGOT and SGPT ≥ 2 x of the upper limits of normal; total bilirubin, of ≥ 1.5 x the upper limits of normal or ≥ 3.0 mg/dl in patients with Gilbert's syndrome. * Administered a radioisotope within 5 physical half lives prior to study enrollment. * Patients with severe claustrophobia unresponsive to oral anxiolytics * Subjects weighing ≥350 lbs or are unable to fit within the imaging gantry * Subjects who have received androgen deprivation therapy. * Subjects with any medical condition or other circumstances that, in the opinion of the Investigator, would significantly decrease obtaining reliable data, achieving study objectives or completing the study.