Effect of Increased Protein Intake on Colonic Metabolism

N/ACompletedNCT01280513

KU Leuven20 enrolled

Overview

The purpose of this study is to modulate the protein fermentation and to investigate the effect on colon toxicity.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Protein Fermentation Toxicity in the Colon

Interventions

High protein intakeDIETARY_SUPPLEMENT

30% of energy intake coming from proteins

Low Protein intakeDIETARY_SUPPLEMENT

9% of energy intake coming from proteins

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy * Regular eating pattern (3 meals/day) * Age between 18 and 45 years old * BMI between 18,5 and 30 kg/m² Exclusion Criteria: * Intake of antibiotics in the last month before the study * Abdominal surgeries in the past (accept appendectomy) * Consulting a dietician/following a diet * Vegetarian * Intake of pre- and/or probiotics * Exposure to radioactivity in the year proceeding the study

Locations (1)

KULeuven

Leuven, Vlaams-Brabant, Belgium

Outcomes

Primary Outcomes

Fecal water toxicity

Time frame: Participants were followed for 5 weeks, with measurements on 3 specific time points

Data from ClinicalTrials.gov

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