Adherence With Fixed Versus Unfixed Glaucoma Therapy

Inclusion Criteria: * Patient is between 21-80 years old * Patient has ocular hypertension or open-angle glaucoma Patient receives therapy and is well controlled on fixed or unfixed latanoprost and timolol therapy * Untreated IOP \>19 mm Hg \<33 mm Hg at baseline (10:00 hour) * Open normal appearing angles * Patient had at least a 20% reduction vs untreated baseline on current therapy * Patient has early or moderate glaucoma (\< 14 decibel; 0.8 or better cupping) * Distance best corrected Snellen visual acuity greater than 1/10 Exclusion Criteria: * Contraindication to timolol or prostaglandin therapy * History of lack of response to any medication (\< 10%) * Patient does not understand the instructions and will not comply to medications * Patient can not attend follow up * Patient is a female of childbearing potential, or lactating mother * History of trauma, inflammation, surgery, past use of steroids (within 2 months), severe dry eyes and use of contact lenses * Sign of ocular infection * A corneal abnormality that may affect IOP measurements