Bleeding Prediction in Patients Following Cardiac Surgery Using Whole Blood Aggregometry and Thromboelastometry

University of Zagreb148 enrolled

Overview

Use of whole blood impedance aggregometry and rotational thromboelastometry can reveal useful data about platelet function and viscoelastic properties of blood clot in patients undergoing cardiac surgery. The purpose of this study is to clarify whether it is possible to predict patients on excessive risk of perioperative bleeding using whole blood impedance aggregometry and rotational thromoelastometry. Antiplatelet therapy is the cornerstone in treatment of patients with coronary artery disease. Another research goal is to determine the degree of response to antiplatelet therapy before and after surgery and to investigate whether patients by level of response to antiplatelet therapy before surgery have a higher risk of perioperative bleeding.

Study Type

OBSERVATIONAL

Enrollment

148

Conditions

Heart Disease Coronary Artery Disease Aortic Valve Disease Mitral Valve Disease

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. \> 18 years old 2. Elective cardiac surgery patients 3. Coronary artery disease 4. Aortic valve disease 5. Mitral valve disease 6. Ascendent aorta aneurysm 7. Combine coronary and valve disease 8. Cardiac surgery procedures using cardiopulmonary bypass Exclusion Criteria: 1. Missing consent 2. Patients with emergent cardiac surgical procedures 3. Patients on antiplatelet therapy other than aspirin or clopidogrel 4. Patients with inaccurate antiplatelet therapy administration documentation 5. Missing data 6. Off-pump procedures 7. Patients younger than 18 years old 8. Patients with severe mental disorders 9. Intrinsic coagulopathy

Outcomes

Primary Outcomes

Chest tube output in first 24 hours

Time frame: 24 hours after surgical procedure

Secondary Outcomes

Allogenic blood products transfusion

Time frame: 7 days after surgery including the day of surgery