Influence of Acid Reflux on Stromal Epithelial Interaction in Barrett's Esophagus

Mayo Clinic48 enrolled

Overview

The purpose of this study is to determine the association between acid reflux and cell changes in Barrett's esophagus. Specific aim 1: To test the hypothesis that controlled acid reflux is associated with lesser degree of stromal activation. Specific aim 2: To test the hypothesis that stromal fibroblast derived growth factors drive BE epithelial proliferation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Barrett's Esophagus

Interventions

24 hour pH study and upper endoscopy (EGD)PROCEDURE

All subjects enrolled will undergo 24 hour pH followed by EGD.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Prior histological demonstration of Barrett's esophagus that is endoscopically visible; length of visible segment \>/= 1 cm 2. Absence of dysplasia or LGD on biopsies within the past 5 years 3. Ability to provide informed consent 4. Age between 18 years and 90 years at study entry. Exclusion criteria: 1. Eastern Cooperative Oncology Group performance status 3 or 4 2. Inability to tolerate endoscopic procedures 3. Pregnancy: Females of child-bearing age will be screened with pregnancy test. 4. Prior esophageal surgery, or cancer

Locations (1)

Mayo Clinic

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

activated myofibroblasts

The primary end point for the study will be the proportion of patients with activated myofibroblasts (defined as positive staining for SMA and vimentin with negative staining for Desmin, in \> 50% of subepithelial myofibroblasts). This primary end point will be compared between the group with controlled acid reflux and the group without acid reflux.

Time frame: 6 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.