Ultrasonographic Monitoring of Response to Infliximab in Patients With Rheumatoid Arthritis

Inclusion Criteria: 1. age 18-65 years, male or female and who are capable of providing informed consent, which must be obtained prior to any study-related procedures. 2. Those who have a definitive diagnosis of RA based on the criteria of American College of Rheumatology in 1987 and have moderate to severe disease (DAS28 more than 3.2). 3. Patients using oral corticosteroids, must have been on a stable dose of prednisone 10mg/day or its equivalent for at least 4 weeks prior to screening. If currently not using corticosteroids the patient must have not received corticosteroids for at least 4 weeks prior to screening. 4. Patients using DMARDs, must have been on a stable dose for at least 12 weeks prior to screening. If currently not using DMARDs the patient must have not received DMARDs for at least 12 weeks prior to screening. 5. If using NSAIDs or other analgesics for RA, must be on a stable dose for at least 2 weeks prior to the first administration of study agent. Exclusion Criteria: 1. Patient who has a known hypersensitivity to human immunoglobulin proteins or other components of infliximab. 2. Patient who suffers from systemic inflammatory disease whose signs and symptoms are expected to affect the evaluation of the study drug. 3. Patient who has a history of receiving infliximab or any other biologics. 4. Patient who has stage IV RA. 5. Patient who has had or is on live viral or bacterial vaccinations within 4 weeks to study entry. 6. Patient who ever suffered from chronic or recurrent infection, including but not limited to: chronic kidney infection, chronic thoracic cavity infection (eg. bronchiectasis), nasosinusitis, recurrent urinary tract infection, open, drain or dermal infected wound.