Assessment of Normal Value of Acoustic Radiation Force Impulse (ARFI) Elastography in HIV Patients

Yonsei University100 enrolled

Overview

This is a prospective cohort single center study for assessment of normal value of acoustic radiation force impulse elastography and fibroscan in HIV patients without abnormal liver function and chronic liver disease.

HIV positive patients who have liver dysfunction have shown to be correlated with high mortality and morbidity. To date, ARFI elastography has been known to correlate with the degree of liver fibrosis in chronic liver disease. However, ARFI velocity has not yet been reported in HIV patients. The aim of this study was to identify the normal range of ARFI velocity and liver stiffness value by recruiting HIV patients without abnormal liver function and chronic liver disease.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

HIV Infection

Interventions

Acoustic radiation force impulse imagingDEVICE

Acoustic radiation force impulse (ARFI) imaging were measured 10 times in each patient.The region of interest was chosen in an area where the normal liver parenchyma was at least 6 cm thick and free of large blood vessels was chosen. A measurement depth of 2 cm below the liver capsule was chosen to standardize the examination.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 20 years * HIV positive patients * The patients who is willing and able to provide written informed consent to participate in this study Exclusion Criteria: * Co-infected with HIV and HBV or HCV * History of any other forms of liver disease * Any gross abnormality on the imaging finding including MRI and CT * Any laboratory abnormalities regarding liver condition (Platelet count \< 150 x 103/ul, Fasting glucose \> 110 mg/dl, AST \> 40 IU/L, ALT\> 40 IU/L, Albumin \< 3.3 g/dl, Total bilirubin \> 1.2 mg/dl, GGT\> 54 IU/L, ALP \> 115 IU/L , Ferritin \> 322 ng/ml)

Locations (1)

Severance Hospital

Seoul, South Korea

RECRUITING

Outcomes

Primary Outcomes

Evaluation of ARFI velocity in HIV patients

Measurement of ARFI velocity is non-invsive ultrasonographic technique. It is performed with a abdominal convex probe which is same probe as conventional ultrasonography. Short-duration acoustic radiation forces result in shear-wave propagation away from the region of excitation and are tracked using ultrasonic correlation-based methods. This results are called ARFI velocity which is expressed as meters per second

Time frame: 2 years

Central Contacts

Seung Up Kim, MD

CONTACT

+82-2-2228-2108 ksukorea@yuhs.ac

Kwang-Hyub Han, MD

CONTACT

+82-2-2228-1949 gihankhys@yuhs.ac

Data from ClinicalTrials.gov

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