Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles

Johns Hopkins University24 enrolled

Overview

The purpose of this study is to assess the comparative efficacy of retinol 1.0% and tretinoin 0.02% in minimizing wrinkles, discoloration, roughness, and other signs of moderate to severe photodamage. Our hypothesis is that both products will be of comparable benefit.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Photodamaged Skin Wrinkles

Interventions

RetinolDRUG

1.0% cream

TretinoinDRUG

0.02% cream

Eligibility

Sex: ALLMin age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 35 or over * Moderate to severe photodamage Exclusion Criteria: * History of facial cosmetic surgery, facial resurfacing procedures, deep peels, or facial fillers * History of keloids or hypertrophic scars * Use of oral steroids or oral retinoids (such as Accutane) in past 6 months

Locations (1)

Johns Hopkins Dept. of Dermatology

Baltimore, Maryland, United States

Outcomes

Primary Outcomes

Global Photodamage Severity

A photonumeric scale for the assessment of cutaneous photodamage (CE Griffiths, et al). Five photographic standards (en face and 45 degrees oblique) illustrating increasing severity of photodamage (min=0, max=8) where 0=no damamge; 2=mild damage; 4=moderate damage; 6=moderate/severe damage; and grade 8=severe damage.

Time frame: Week 24

Data from ClinicalTrials.gov

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