The purpose of this study is to evaluate the efficacy of teprenone on chronic non-atrophic erosive gastritis and its therapeutic mechanism
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
156
Teprenone 1 capsule (50mg)+placebo of sucralfate 4tab, tid×8 weeks.
Placebo of teprenone 1 capsule+ sucralfate 4 tab(1.0), tid×8 weeks
Tongren Hospital
Beijing, Beijing Municipality, China
Zhongshan Hospital of Xiamen University
Xiamen, Guangdong, China
First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, China
First Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, China
The difference of the modified Lanza score after 4 weeks of treatment between teprenone group and sucralfate group
Time frame: 0,4 weeks
The difference of total effective rate after 4 weeks treatment evaluated by histologic examination on inflammation improvement between teprenone group and sucralfate group
Time frame: 4 weeks
The difference of patients' gastric mucosal concentration of hexosamine, PGE2 and HSP70 after 4 weeks treatment between teprenone group and sucralfate group
Time frame: 4 weeks
The difference of total effective rate after 4 and 8 weeks treatment evaluated by clinical symptom score between teprenone group and sucralfate group
Time frame: 4 and 8 weeks
The difference of total effective rate after 8 weeks treatment evaluated by endoscopy between teprenone group and sucralfate group
Time frame: 8 weeks
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Changhai Hospital
Shanghai, Shanghai Municipality, China
Shanghai Xinhua Hospital
Shanghai, Shanghai Municipality, China
First Affiliated Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
General Hospital of Tianjin Medical University
Tianjin, Tianjin Municipality, China