The purpose of this study is to measure the level of medicines found in body fluids such as blood, urine, spinal fluid of children.
There is a lack of safety, pharmacokinetic and efficacy data of therapeutic agents in children and infants. Samples used for measurement will be from scavenged samples. i.e. any extra blood/body fluid samples from a test done as part of the standard of care.
Study Type
OBSERVATIONAL
Enrollment
400
University of North Carolina NC Children's Hospital
Chapel Hill, North Carolina, United States
RECRUITINGArea under the curve (AUC)
actual body exposure to drug after a dose of the drug is administered. this is dependent on on the rate of drug elimination divided by plasma concentration of the drug.
Time frame: approximately 10-21 days.The time frame for the outcome measure may vary depending on the length of the course of the medication.
Volume of distribution at steady-state
Volume of distribution is defined as the theoretical volume in which the total amount of drug would need to be uniformly distributed to produce the desired blood concentration of a drug. Vss is the apparent volume of distribution at steady-state.
Time frame: approximately 10-21 days. The time frame for the outcome measure may vary depending on the length of the course of the medication.
Terminal elimination rate constant (Ke) and Half-Life
Period of time that it takes for the concentration of the drug in the body to be reduced by on-half.
Time frame: approximately 10-21 days. The time frame for the outcome measure may vary depending on the length of the course of the medication.
Plasma Clearance
the rate at which the drug is eliminated from the body divided by the plasma concentration.
Time frame: approximately 10-21 days. The time frame for the outcome measure may vary depending on the length of the course of the medication.
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