Study to Improve Renal Function After Kidney Transplantation

Inclusion Criteria: 1. Males and females ≥ 18 years of age 2. Had renal transplantation due to end stage disease requiring chronic dialysis 3. Study drug can be administered within 36 hours after transplantation 4. Received kidney from healthy donor or donor with history of diabetes mellitus or hypertension 5. Donor terminal serum creatinine ≤ 2.2 mg/dL. 6. No urine output, OR average urine output of \< 50 cc/H over 8 or more consecutive hours, OR normal urine output following transplantation that diminished to average of \< 50 cc/H over 8 or more consecutive hours, OR creatinine reduction ratio at 24 hours after transplantation to pre-transplantation is \< 30%. 7. Reason for low urine output is unlikely due to structural changes. If clinically indicated, an ultrasound will be performed 8. Dry weight to\< 120kg and BMI \<35 9. Women of child bearing potential have a negative serum pregnancy test prior to transplantation. 10. Women of child bearing potential (including perimenopausal women who have had a menstrual period within 1 year) must agree to use 2 forms of effective birth control regimen (at least one-barrier method) during the 28-day study period. Men must agree to use condoms during the 28-day study period. 11. In the opinion of the investigator, the subject is capable of understanding and complying with the protocol. 12. Subjects must have signed the informed consent document prior to performance of any study related procedure including screening procedure. Exclusion Criteria: 1. Subject with normal urine output and not requiring dialysis prior to renal transplantation (i.e., had pre-emptive renal transplantation). 2. Signs and symptoms of volume depletion. 3. Recipient of multiple organ transplantation or scheduled for multiple organ transplantation. 4. Recipient of pediatric en-bloc kidney transplantation. 5. Recipient of kidney with cold ischemia time \> 40 hours 6. Has measurable donor-specific antibody or positive cross-match requiring deviation from standard immunosuppressive therapy. 7. Currently participating in or has participated in an investigational drug or medical device study within 30 days or five half-lives, whichever is longer, prior to enrollment into this study. 8. Concurrent sepsis or active bacterial infection. 9. Have an active malignancy or history of solid, metastatic or hematologic malignancy with the exception of basal or squamous cell carcinoma of the skin that has been removed. 10. Women of child bearing potential who are breast feeding. 11. History of positive HIV test. 12. History of rheumatoid arthritis. 13. Subjects who require the cytochrome P450 1A2 (CYP1A2) inhibitors, ciprofloxacin and/or fluvoxamine (Luvox®) 14. Subject is unwilling or unable to comply with the protocol or to cooperate fully with the Investigator or the site personnel. 15. Subject is not deemed medically stable for the study in the opinion of the Investigator or the subject's primary nephrologist.