Study to Evaluate Switching From a Regimen Consisting of the Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate Single-Tablet Regimen (STR) to the Emtricitabine/Rilpivirine/Tenofovir Disoproxil Fumarate STR

Inclusion Criteria: * Ability to understand and sign a written informed consent form * Receiving EFV/FTC/TDF continuously for ≥ 3 months preceding the screening visit * Plasma HIV-1 RNA concentrations (at least two measurements) at undetectable levels for ≥ 8 weeks prior to the screening visit and HIV-1 RNA \< 50 copies/mL at the screening visit * On their first antiretroviral drug regimen, and no HIV-1 RNA \> 50 copies/mL measured at two consecutive time points after first achieving HIV RNA \< 50 copies/mL * Had a genotype prior to starting FTC/RPV/TDF and no known resistance to any of the study agents * Normal ECG * Hepatic transaminases (AST and ALT) ≤ 5 x upper limit of normal (ULN) * Total bilirubin ≤ 1.5 mg/dL, or normal direct bilirubin * Adequate hematologic function (absolute neutrophil count ≥ 1,000/mm\^3; platelets ≥ 50,000/mm\^3; hemoglobin ≥ 8.5 g/dL) * Serum amylase ≤ 5 x ULN (subjects with serum amylase \> 5 x ULN eligible if serum lipase ≤ 5 x ULN) * Adequate renal function (estimated glomerular filtration rate ≥ 50 mL/min according to the Cockcroft-Gault formula) * Males and Females of childbearing potential must have agreed to utilize highly effective contraception methods (two separate forms of contraception, one of which must be an effective barrier method, or be nonheterosexually active, practice sexual abstinence, or have a vasectomized partner) from screening throughout the duration of the study period and for 60 days following the last dose of study drug. * Age ≥ 18 years * Life expectancy ≥ 1 year Exclusion Criteria: * A new AIDS-defining condition diagnosed within 21 days prior to screening * Females who were breastfeeding * Positive serum pregnancy test (female of childbearing potential) * Proven or suspected acute hepatitis in the 21 days prior to study entry * Subjects receiving drug treatment for Hepatitis C, or subjects anticipated to receive treatment for Hepatitis C during the course of the study, or with a history of liver disease * Was experiencing decompensated cirrhosis * Implanted defibrillator or pacemaker * Current alcohol or substance abuse judged by the Investigator to potentially interfere with subject compliance * History of malignancy within the past 5 years or ongoing malignancy other than cutaneous Kaposi's sarcoma, basal cell carcinoma, or resected, noninvasive cutaneous squamous carcinoma * Active, serious infections requiring parenteral antibiotic or antifungal therapy within 21 days prior to Baseline * All investigational drugs * Ongoing therapy or anticipated need to initiate drugs or herbal/natural supplements during the study that were contraindicated or not recommended for use as indicated in the protocol, including drugs not to be used with FTC, RPV, and TDF; or subjects with known allergies to the excipients of the FTC/RPV/TDF STR * Participation in any other clinical trial without prior approval from the sponsor was prohibited while participating in this trial * Treatment with immunosuppressant therapies or chemotherapeutic agents within 3 months of study screening, or expected to receive these agents or systemic steroids during the study (eg, corticosteroids, immunoglobulins, and other immune- or cytokine-based therapies) * Any other clinical condition or prior therapy that, in the opinion of the Investigator, would make the subject unsuitable for the study or unable to comply with the dosing requirements