A Study of Irinotecan, Levofolinate, and 5-Fluorouracil (FOLFIRI) Plus Ramucirumab (IMC-1121B)

Inclusion Criteria: * Participant is Japanese * Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 * Has histologically or cytologically confirmed CRC * Has metastatic disease that is not amenable to potentially curative resection * Has received no more than 2 prior systemic chemotherapy regimens in any setting (only 1 prior regimen for metastatic disease is permitted) * Has received first-line combination therapy of bevacizumab, oxaliplatin, and a fluoropyrimidine for metastatic disease and has experienced disease progression during first-line therapy, or disease progression within 6 months after the last dose of first-line therapy, or discontinued part or all of first-line therapy due to toxicity and experienced disease progression within 6 months after the last dose of first-line therapy. Participants must have received a minimum of 2 doses of bevacizumab as part of a first-line regimen containing chemotherapy in order to enroll. * Has adequate hepatic, renal, hematologic, and coagulation function * The participant's urinary protein is ≤1+ on dipstick or routine urinalysis. If urine dipstick or routine analysis indicates proteinuria ≥2+, then a 24-hour urine must be collected and must demonstrate \<1000 milligrams (mg) of protein in 24 hours to allow participation in the study Exclusion Criteria: * Has received bevacizumab within 28 days prior to study registration * Has received chemotherapy within 21 days prior to study registration * Has received any previous systemic therapy (other than a combination of bevacizumab, oxaliplatin, and a fluoropyrimidine) for first-line treatment of metastatic CRC * The participant experienced any of the following during first-line therapy with a bevacizumab-containing regimen: an arterial thrombotic/thromboembolic event; Grade 4 hypertension; Grade 4 proteinuria; a Grade 3-4 bleeding event; or bowel perforation * Has received wide-field (full-dose pelvic) radiotherapy within 28 days prior to study registration * Has undergone major surgery within 28 days or subcutaneous venous access device placement within 7 days prior to study registration * Has elective or planned surgery to be conducted during the trial * Has a history of deep vein thrombosis or pulmonary embolism within the past 12 months * Has experienced any arterial thrombotic event within the past 12 months * Participant is receiving therapeutic anticoagulation with warfarin, low-molecular weight heparin, or similar agents * Participant is receiving chronic therapy with nonsteroidal anti-inflammatory agents \[Aspirin up to 325 milligrams per day (mg/day) permitted\] * Has a significant bleeding disorder or has had a significant (Grade 3 or higher) bleeding event within 3 months prior to registration date * Has a history of gastrointestinal perforation and/or fistulae within 6 months prior to registration date * Has symptomatic congestive heart failure, unstable angina pectoris, or symptomatic or poorly controlled cardiac arrhythmia * Has uncontrolled arterial hypertension despite standard medical management * Has a serious or nonhealing wound, peptic ulcer, or bone fracture within 28 days prior to study registration * Has an acute/subacute bowel obstruction or history of clinically significant chronic diarrhea * Has a history of inflammatory bowel disease or Crohn's disease requiring medical intervention within 12 months prior to registration date * The participant has either peptic ulcer disease associated with a bleeding event or known active diverticulitis * Has an active infection requiring antibiotic, antifungal, or antiviral therapy * Has known human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS)-related illness * Has known leptomeningeal or brain metastases or uncontrolled spinal cord compression * Has a known history of Gilbert's Syndrome, or is known to have any of the following genotypes: uridine diphosphate glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1)\*6/\*6; UGT1A1\*28/\*28 or UGT1A1\*6/\*28 * Has previous or concurrent malignancy, except for basal or squamous cell skin cancer and/or in situ carcinoma, or other solid tumors treated curatively and without evidence of recurrence for at least 3 years