A 3-Part Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0980, the Effect of Food, and the Effect of Rabeprazole on the Pharmacokinetics of the Tablet

Inclusion Criteria * Nonsmoking with a body mass index of 18 to 32 kg/m2 * Medically healthy as determined by the absence of clinically significant findings in the physical examination, medical history, vital sign measurements, clinical laboratory tests, or 12-lead electrocardiograms (ECGs) * Nonchildbearing potential, defined as either postmenopausal and without recent history of menorrhea or surgically sterile Exclusion Criteria * History or clinical manifestations of significant metabolic, hepatic, renal, hematological, pulmonary, cardiovascular, endocrine, gastrointestinal, urological, neurological, or psychiatric disorders, or cancer * History of inflammatory arthritis * History of symptomatic hypotension * History of severe physical injury, direct impact trauma, or neurological trauma within 6 months prior to study start * History of seizure disorders * History of bipolar or major depressive disorder * History of stomach or intestinal surgery or resection that could potentially alter absorption and/or excretion of orally administered drugs with the exception of appendectomy, hernia repair, and cholecystectomy, which are allowed * History or presence of an abnormal ECG * History of ventricular dysrhythmias or risk factors for ventricular dysrhythmias * Abnormality on the chest x-ray at Screening * History of alcoholism, drug abuse, or drug addiction * Used any nicotine-containing or nicotine-replacement products within 6 months prior to study start * Participated in any other investigational drug study in which receipt of an investigational study drug occurred within 1 month or 5 half-lives prior to study start * Used any prescription medications/products including monoamine oxidase inhibitors, thioridazine, pimozide, or antidepressants within 1 month (2 weeks for antibiotics) prior to study start, with the exception of hormone-replacement therapy or 2 weeks' use of narcotics for pain * Received any vaccination or immunization within 1 month prior to study start * Used PPIs or histamine H2-receptor antagonists within 1 month prior to study start * Hypersensitivity to rabeprazole, or any of its components, or to derived products of benzimidazoles (for Part 3 only) * Poor peripheral venous access * Received blood products within 2 months prior to study start * Positive urine drug or alcohol screen * Positive screen for hepatitis B surface antigen, hepatitis C virus, or human immunodeficiency virus types 1 and 2 * Unable to consume a high-fat meal (for Parts 2 and 3 only) * Acute or chronic condition that would limit the subject's ability to complete or participate in this clinical study