The majority of elderly patients with a displaced fracture of the proximal femur are now treated with a hemiarthroplasty. Prosthetic joint infection is a devastating complication, and the infection rate is high in this group of elderly patients. Local application of gentamicin produces high antibiotic concentrations in the wound. The aim of this study is to determine whether locally administered collagen-gentamicin in the joint perioperatively in addition to routine IV prophylaxis with beta-lactam antibiotics can reduce the early postoperative infection rate (\< 4 weeks postoperative)after hemiarthroplasty in proximal femoral fractures.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
800
A 10 by 10 cm sponge consisting of 280 mg collagen and 130 mg gentamicin.Two sponges are inserted during hemiarthroplasty surgery, one in the joint and one underneath the fascia at the time of surgical closure.
Buskerud Hospital, Drammen
Drammen, Drammen, Norway
Elverum Hospital
Elverum, Elverum, Norway
Oslo University Hospital, Ullevål
Oslo, Oslo County, Norway
Asker and Bærum Hospital
Bærum, Rud, Norway
Diakonhjemmets Hospital
Oslo, Norway
Number of patients with postoperatively infection after hemiarthroplasty to evaluate locally administered collagen-gentamicin peroperatively
A randomized multicentre trial
Time frame: Within 4 weeks after prosthetic surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.