The investigators have previously demonstrated the utility of transdermal testosterone in in vitro fertilization (IVF) low responder patients. Now, the investigators want to evaluate the efficacy of luteinizing hormone (LH) activity added to recombinant follicular stimulating hormone (FSHr) during ovarian stimulation in these patients.
Studies in macaques have indicated that androgens have some synergistic effects with follicular stimulating hormone (FSH) on folliculogenesis. Our previous clinical studies demonstrated the usefulness of pretreatment with transdermal testosterone in low-responder IVF patients. There is controversy on the usefulness of recombinant luteinizing hormone (LHr) added to FSHr in ovarian stimulation of low responder patients. Thus, our present study has been designed to compare ovarian stimulation with FSHr alone versus LHr added to FSHr when transdermal testosterone pretreatment is used.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
104
75U of LHr added to FSHr ovarian stimulation in IVF, when testosterone was used to improve the ovarian response
FSHr alone used in ovarian stimulation in IVF, when testosterone was used to improve the ovarian response
Hospital Clínic
Barcelona, Barcelona, Spain
ovarian response
number of oocytes obtained per ovarian stimulation cycle
Time frame: within 2 weeks after begining ovarian stimulation
clinical pregnancy rate
The number of clinical pregnancies expressed per embryo transfer cycles. Clinical pregnancy: a pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs or definitive clinical signs of pregnancy. It includes ectopic pregnancy. Multiple gestational sacs are counted as one clinical pregnancy.
Time frame: within 5 weeks (plus or minus 1 week) after embryo transfer
Implantation rate
The number of gestational sacs (observed by ultrasound examination) divided by the number of embryos transferred.
Time frame: within 5 weeks (plus/minus 1 week) after embryo transfer
Live birth rate
The number of deliveries that resulted in at least one live born baby expressed per 100 embryo transfer cycles.
Time frame: within 9 months (plus/minus 1 month) after embryo transfer
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