Triclosan Toothpaste and Third Molar Surgery

University of Rochester141 enrolled

Overview

Triclosan containing dentifrices are effective in the prevention of inflammatory complications following third molar surgery through reducing preoperative oral bacteria load.

This study may provide evidence on the effect of triclosan containing dentifrice on oral bacteria and oral inflammation prior to third molar surgery, and on the incidence of inflammatory complications after the surgery. If proven effective, dentifrice containing triclosan may be recommended prior to tooth extractions and replace antibiotics and other antimicrobial products as a prophylactic procedure before oral surgery procedures.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

141

Conditions

Dry Socket Wound Infection

Interventions

Colgate Total ToothpasteOTHER

Toothbrushing with Colgate Total Toothpaste

Colgate Regular ToothpasteOTHER

Toothbrushing with Colgate regular toothpaste

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * must include at least one mandibular third molar with partial or full bony impaction * no sign of active pericoronal (around the crown) infections * must have not taken antibiotics for any reason in the past 30 days * must be healthy and between 18 and 35 years of age * must be able to read and sign an informed consent Exclusion Criteria: * Subjects with systemic diseases and pregnant or lactating women * Subjects with advanced periodontal diseases or having two or more untreated caries lesions * Subjects who cannot read and sign an informed consent * Subjects with signs of pericoronal infections

Locations (1)

University of Rochester Eastman Dental Center

Rochester, New York, United States

Outcomes

Primary Outcomes

dry socket

Development of dry socket (alveolar osteitis) 3 to 7 days after tooth extraction

Time frame: 3 to 7 days

Secondary Outcomes

wound infection

Development of tooth extraction wound infection 3 to 7 days after extraction

Time frame: 3 to 7 days

Data from ClinicalTrials.gov

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