A Study to Evaluate the Interaction of LX4211 and Metformin in Healthy Subjects

Inclusion Criteria: * Adults ≥18 to ≤55 years of age. Females must be of non-childbearing potential. * Body mass index (BMI)≥18 to ≤35 kg/sq m * Able to provide written consent * Vital signs within sponsor-defined ranges Exclusion Criteria: * Use of any medication, including any prescription, over-the-counter, herbal tea, or other supplements within 5 days of dosing * No investigational agent or study treatment within 30 days prior to Day 1. * No protein or antibody-based therapeutic agents within 3 months prior to screening * Use of any tobacco product * History of bariatric surgery or any gastrointestinal surgery that may induce malabsorption * History of any major surgery within 6 months prior to screening * History of any serious adverse reaction or hypersensitivity to metformin or LX4211. * History of renal disease or significantly abnormal kidney function test * History of hepatic disease or significantly abnormal liver function test * History of any active infection within 30 days prior to Day 1 * History of any surgical or medical condition or clinically significant laboratory or physical finding * Positive urine glucose at Screening * Use of drugs or alcohol