* Preliminary scientific studies, in both animals and humans suggest that oral consumption of hydrolyzed collagen acts on the bone remodeling process by stimulating the activity of osteoblasts responsible for bone formation while improving the bone mineral density and biomechanical resistance of long bones. * The objective of this clinical research is to measure changes in biomarkers of bone turnover in postmenopausal healthy women, not osteoporotic, in response to consumption of hydrolyzed collagen for three months. * For this, we propose to measure blood and urinary markers of formation and bone resorption before consumption, then 45 and 90 days after daily consumption of 10 g of hydrolyzed collagen.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
QUADRUPLE
Enrollment
44
10g/day at breakfast during 90 days
10g/day at breakfast during 90 days
CRNH - Centre de Recherche sur Volontaires - Hôpital AVICENNE
Bobigny, Seine-saint-denis, France
Serum C-terminal telopeptide of type 1 collagen (CTX)
MARKERS OF BONE RESORPTION : change from Baseline (Day 0) in serum CTX at 45 days
Time frame: Day 45
Urinary telopeptide N-terminal of type 1 collagen (NTX)
MARKERS OF BONE RESORPTION : change from Baseline (Day 0) in urinary NTX at 45 days
Time frame: Day 45
Serum osteocalcin
MARKERS OF BONE FORMATION : change from Baseline (Day 0) in serum osteocalcin at 45 days
Time frame: Day 45
Serum bone alkaline phosphatase
MARKERS OF BONE FORMATION: change from Baseline (Day 0) in serum bone alkaline phosphatase at 45 days
Time frame: Day 45
Serum amino-terminal pro-peptide of type 1 procollagen (P1NP)
MARKERS OF BONE FORMATION : change from Baseline (Day 0) in serum P1NP at 45 days
Time frame: Day 45
Urinary telopeptide N-terminal of type 1 collagen (NTX)
MARKERS OF BONE RESORPTION : change from Baseline (Day 0) in urinary NTX at 90 days
Time frame: Day 90
Serum osteocalcin
MARKERS OF BONE FORMATION : change from Baseline (Day 0) in serum osteocalcin at 90 days
Time frame: Day 90
Serum bone alkaline phosphatase
MARKERS OF BONE FORMATION: change from Baseline (Day 0) in serum bone alkaline phosphatase at 90 days
Time frame: Day 90
Serum amino-terminal pro-peptide of type 1 procollagen (P1NP)
MARKERS OF BONE FORMATION : change from Baseline (Day 0) in serum P1NP at 90 days
Time frame: Day 90
Serum C-terminal telopeptide of type 1 collagen (CTX)
MARKERS OF BONE RESORPTION : change from Baseline (Day 0) in serum CTX at 90 days
Time frame: Day 90
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