Propofol is routinely used for general anesthesia during pediatric heart catheterisation. Propofol infusion syndrome (PRIS) is a rare, but often fatal complication mainly defined by bradycardia with progress to asystolia during propofol infusion. Metabolic acidosis is regarded as an early warning sign of PRIS. In this study the effect of propofol and sevoflurane on serum base excess, pH and lactate are examined during pediatric heart catheterisation.
In this prospective randomised study 40 children are anesthetised for pediatric heart catheterisation with propofol (N = 22) or sevoflurane (N = 18) with ethic committee approval. Base excess, pH and lactate were measured by blood gas analysis at the beginning, during and at the end of the procedure. Changes relative to baseline were analysed by paired t-Test with correction for multiple testing. The study was powered to detect a difference of 1.5 mmol/l for base excess and lactate.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SCREENING
Masking
NONE
Enrollment
40
Anesthesia is switched from sevoflurane to propofol after obtaining a baseline blood gas analysis.
University Hospital Schleswig-Holstein, Campus Kiel
Kiel, Schleswig-Holstein, Germany
Serum Lactate
Serum lactate is measured during application of propofol and sevoflurane to examine the effect on metabolic acidosis.
Time frame: 4 hours
pH and base excess
pH and base excess are measured during application of Propofol and Sevoflurane to examine the effect on acid-base balance
Time frame: Hours
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.